منابع مشابه
Dmd057984 1090..1097
Studies were conducted to evaluate the impact of time and cryopreservation on aldehyde oxidase (AO) activity in human hepatocytes isolated from 10 donor livers, using O-benzylguanine as a probe substrate. In addition, variability in activity was assessed using cryopreserved hepatocytes from 75 donors. Substantial donor-dependent loss in AO activity within 24 hours after isolation of hepatocytes...
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George Serafeim is an assistant professor of business administration at Harvard Business School and a member of the SASB Standards Council.
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Prior work demonstrates that mammalian microRNA (miRNA or miR) expression requires RNA polymerase II (Pol II). However, the transcriptional requirements of many miRNAs remain untested. Our genomic analysis of miRNAs in the human chromosome 19 miRNA cluster (C19MC) revealed that they are interspersed among Alu repeats. Because Alu transcription occurs through RNA Pol III recruitment, and we foun...
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1106 Once upon a time, the world seemed simple when viewed through the eyes of evolutionary biologists. All genomes were tightly controlled by various forms of natural selection. DNA encoded functional genes, and most mutations that occurred were rejected through negative selection. Those exceptional mutations that were beneficial substituted for the original gene variant (allele) and spread th...
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ژورنال
عنوان ژورنال: Synthesis
سال: 1997
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-1997-4477